What makes you get out of bed every day? My kids, I get up each morning to take care of them.What do you consider is your "brightest" quality? I have a very strong work ethic.What's your favorite aspect of your job? Helping my clients and being their trusted advisor.In addition to that, I love working with my clients. Why do you choose to work at Rea? The people at Rea are great! I enjoy working with them each and every day.What does "A Brighter Way" mean to you? It means understanding our clients' needs and proactively providing them solutions to succeed.Attending a sporting event for her children.Spending time with her husband, Bob and their three children.When she's not in the office, you can find her: She has over 25 years of accounting experience.įurthering her professional development, Lisa is involved with:.Lisa earned her bachelor's degree in accounting from the University of Akron. We have estimated Lisa Beamers net worth, money, salary, income, and assets. So, how much is Lisa Beamer worth at the age of 52 years old Lisa Beamer’s income source is mostly from being a successful Writer. doi: 10.1038/s41597-w.Topics or areas of expertise that Lisa can talk about (even in her sleep): Lisa Beamer Net Worth Her net worth has been growing significantly in 2020-2021. Multiple Ligand-Bound States of a Phosphohexomutase Revealed by Principal Component Analysis of NMR Peak Shifts. Xu J, Sarma AVS, Wei Y, Beamer LJ, Van Doren SR. A Hotspot for Disease-Associated Variants of Human PGM1 Is Associated with Impaired Ligand Binding and Loop Dynamics. The Metabolic Map into the Pathomechanism and Treatment of PGM1-CDG. Radenkovic S, Bird MJ, Emmerzaal TL, Wong SY, Felgueira C, Stiers KM, Sabbagh L, Himmelreich N, Poschet G, Windmolders P, Verheijen J, Witters P, Altassan R, Honzik T, Eminoglu TF, James PM, Edmondson AC, Hertecant J, Kozicz T, Thiel C, Vermeersch P, Cassiman D, Beamer L, Morava E, Ghesquière B. Structural and dynamical description of the enzymatic reaction of a phosphohexomutase. Stiers KM, Graham AC, Zhu JS, Jakeman DL, Nix JC, Beamer LJ. Inhibitory Evaluation of αPMM/PGM from Pseudomonas aeruginosa: Chemical Synthesis, Enzyme Kinetics, and Protein Crystallographic Study. Zhu JS, Stiers KM, Soleimani E, Groves BR, Beamer LJ, Jakeman DL. Impaired folate binding of serine hydroxymethyltransferase 8 from soybean underlies resistance to the soybean cyst nematode. Korasick DA, Kandoth PK, Tanner JJ, Mitchum MG, Beamer LJ. A missense variant remote from the active site impairs stability of human phosphoglucomutase 1. Stiers KM, Hansen RP, Daghlas BA, Mason KN, Zhu JS, Jakeman DL, Beamer LJ. (2021) Enzyme dysfunction at atomic resolution: disease-associated variants of human phosphoglucomutase-1. Program Director, Annual meeting of the American Crystallographic Association, 2004īeamer LJ.Chair, BIOMAC Special Interest Group American Crystallographic Association.Editor, Acta Crystallographica F: Structural Biology and Crystallization Communications, 2009-2017.Session chair, 2018 annual meeting of the American Crystallographic Association.A better understanding of the molecular bases of this inherited disease should benefit patient prognosis and therapy. We have found that different mutations have profoundly different effects on enzyme structure and activity. In particular, we are studying amino acid variants responsible for a deficiency in the enzyme phosphoglucomutase 1 (PGM1). Current goals include developing new ways to engineer SCN resistance to help combat this critical agricultural pathogen.Īnother recent project involves using structural biology to understand the consequences of mutations that cause inherited disease in humans. Our initial structural and biochemical studies showed that these amino acid variants impair the binding of folate to SHMT8. Amino acid variants in this enzyme, serine hydroxymethyltransferase 8 (SHMT8), are associated with resistance to the devastating pathogen soybean cyst nematode (SCN). The project involves studies of a soybean enzyme involved in folate metabolism. In addition to crystallography, we use methods such as enzyme kinetics, small angle X-ray scattering, and hydrogen deuterium exchange, as well as various bioinformatic and computational approaches.Īn ongoing effort in the lab is an NSF-funded project in collaboration with plant scientist Melissa Mitchum from the University of Georgia. Our overall focus is characterizing enzymes in various metabolic pathways, in organisms ranging from bacteria to plants to humans. A primary technique employed by the laboratory is X-ray crystallography, which provides atomic resolution information on the three-dimensional structures of macromolecules. Our laboratory uses structural biology and other biophysical methods to characterize enzyme function. Structural biology: X-ray crystallography of metabolic enzymes biophysical studies of disease-related missense variants Research Description
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